Cross-Sectional Comparison of Sleep-Disordered Breathing in Native Peruvian Highlanders and Lowlanders.

Pham, V. Luu, Christopher Meinzen, Rafael S. Arias, Noah G. Schwartz, Adi Rattner, Catherine H. Miele, Philip L. Smith, Hartmut Schneider, J. Jaime Miranda, Robert H. Gilman, Vsevolod Y. Polotsky, William Checkley, and Alan R. Schwartz. comparative cross-sectional study of sleep-disordered breathing in the original Peruvian highlands and lowlands. High Alt Med Biol. 18: 11-19, 2017.


BACKGROUND
Altitude can highlight irregular sleep breathing (SDB), which has been associated with cardiovascular and metabolic diseases. SDB on the plateau is not marked in large controlled studies. The purpose of this study was to compare the prevalence and severity of SDB in the highlands and lowlands.


METHOD
170 age, body-mass Index, (BMI), and gender couples (age 58.2 ± 12.4 years, BMI 27.2 ± 3.5 kg / m2, and 86 male and 84 female) from Crónicas Cohort Study recruited at sea level (Lima) and high altitude (Puno, 3825 m) arrangements in Peru. Participants underwent nocturnal polygraph simultaneously and actigraphy to characterize patterns of breathing, movement arousals, and sleep / wake state. We compared the prevalence of SDB, type, and severity between the highlands and lowlands as measured by the apnea-hypopnea index (AHI) and pulse oximetry (SpO2) during sleep.


RESULTS
Greater prevalence of sleep apnea in the highlands than in the lowlands (77% vs 54%, p <0.001). Compared with the lowlands, highlands have a two-fold increase in AHI due to the increase in the central rather than obstructive apnea. On the plateau compared with the lowlands, lower SpO2 during wakefulness and a further decrease during sleep (p <0.001). Hypoxemia during wakefulness predict sleep apnea in the highlands, and it seems to mediate the effects of altitude on the prevalence of sleep apnea. Surprisingly, hypoxemia also quite common in the lowlands, and it is also associated with an increased likelihood of sleep apnea.


CONCLUSION
high altitude and hypoxemia at both high and low altitudes associated with an increased prevalence and severity of SDB. Our findings show that most of the highlands remain at risk for SDB sequelae.

 Cross-Sectional Comparison of Sleep-Disordered Breathing in Native Peruvian Highlanders and Lowlanders.
Cross-Sectional Comparison of Sleep-Disordered Breathing in Native Peruvian Highlanders and Lowlanders.

Increased Cardiometabolic Risk and Worsening hypoxemia at High Altitude.

Miele, Catherine H., Alan R. Schwartz, Robert H. Gilman, Luu Pham, Robert A. Wise, Victor G. Davila-Roman, Jonathan C. June, Vsevolod Y. Polotsky, J. Jaime Miranda, Fabiola Leon-Velarde and William Checkley. Increased risk of cardiometabolic and worsening hypoxemia at high altitude. High Alt Med Biol. 17: 93-100 syndrome, 2016.-Metabolic, insulin resistance, diabetes, and dyslipidemia associated with an increased risk of cardiovascular disease.

While excessive erythrocytosis is associated with cardiovascular complications, it is not clear how the worsening hypoxemia of any level affecting cardiometabolic risk factors in a population of high altitude. We studied the relationship between lunch break oxyhemoglobin saturation and cardiometabolic risk factors in adult participants who stay in Puno, Peru (3825 m asl). We used multivariable logistic regression model to study the relationship between having a lower oxyhemoglobin saturation and cardiometabolic risk markers.

BMP-7 CHO

PR27001 2 ug
EUR 191

BMP-7 Antibody

5677-100
EUR 359

BMP-7 Antibody

5677R-100
EUR 316

BMP-7 Antibody

5677R-30T
EUR 146

BMP 7 antibody

20R-1847 100 ug
EUR 673
Description: Rabbit polyclonal BMP 7 antibody

BMP 7 antibody

20R-1848 100 ug
EUR 651
Description: Goat polyclonal BMP 7 antibody

BMP-7 Polyclonal Antibody

ES1779-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against BMP-7 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

BMP-7 Polyclonal Antibody

ES1779-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against BMP-7 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

BMP-7 Polyclonal Antibody

ABP50780-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of BMP-7 from Human, Mouse, Rat. This BMP-7 antibody is for WB , IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human BMP-7

BMP-7 Polyclonal Antibody

ABP50780-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of BMP-7 from Human, Mouse, Rat. This BMP-7 antibody is for WB , IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human BMP-7

BMP-7 Polyclonal Antibody

ABP50780-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of BMP-7 from Human, Mouse, Rat. This BMP-7 antibody is for WB , IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human BMP-7

Anti-BMP-7 antibody

STJ91868 200 µl
EUR 197
Description: Rabbit polyclonal to BMP-7.

Human BMP-7 Antibody

32701-05111 150 ug
EUR 261

BMP-7 Polyclonal Antibody

40651-100ul 100ul
EUR 252

BMP-7 Polyclonal Antibody

40651-50ul 50ul
EUR 187

BMP-7, human recombinant

4579-10
EUR 256

BMP-7, human recombinant

4579-1000
EUR 4563

BMP-7, human recombinant

4579-50
EUR 615

BMP-7 Recombinant Protein

40-641 2 ug
EUR 259.25
Description: TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth, and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling, and maintenance of a variety of other tissues and organs. BMP-7, also known as osteogenic protein-1 or OP-1, is a potent bone inducing agent, which in the presence of an appropriate osteoconductive carrier (e.g. collagen sponge or synthetic hydroxyapatite) can be used in the treatment of bone defects. A bone-graft substitute, called OP-1TM implant, made of recombinant human BMP-7 associated with bovine bone-derived collagen, has recently been approved by the FDA as a device for treating critical-size bone fractures. The potential use of BMP-7 in dental reconstructive surgeries is currently under investigation. Recombinant Human BMP-7 is a 28.8 kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 315 to 431 of the full-length BMP-7 precursor.

BMP-7 Recombinant Protein

40-642 2 ug
EUR 259.25
Description: TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth, and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling, and maintenance of a variety of other tissues and organs. BMP-7, also known as osteogenic protein-1 or OP-1, is a potent bone inducing agent, which in the presence of an appropriate osteoconductive carrier (e.g. collagen sponge or synthetic hydroxyapatite) can be used in the treatment of bone defects. A bone-graft substitute, called OP-1TM implant, made of recombinant human BMP-7 associated with bovine bone-derived collagen, has recently been approved by the FDA as a device for treating critical-size bone fractures. The potential use of BMP-7 in dental reconstructive surgeries is currently under investigation. Recombinant Human BMP-7 is a homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 315 to 431 of the full-length BMP-7 precursor. Recombinant Human BMP-7 has a calculated molecular weight of 26.4 kDa; however, due to glycosylation, the BMP-7 homodimer migrates at an apparent molecular weight of approximately 25-35 kDa by SDS-PAGE analysis under non-reducing conditions.

Bone Morphogenetic Protein 7 (BMP-7) Antibody

abx411168-1ml 1 ml
EUR 509

Bone Morphogenetic Protein 7 (BMP-7) Antibody

abx412613-50ug 50 ug
EUR 509

BMP-7, Bone Morphogenetic Protein-7, human

RC219-18 2ug
EUR 104.38

Human BMP-7 ELISA Kit

RK00239 96 Tests
EUR 521

BMP-7 Polyclonal Conjugated Antibody

C40651 100ul
EUR 397

BMP-7 ELISA KIT|Human

EF000036 96 Tests
EUR 689

Human BMP-7 ELISA Kit

LF-EK50940 1×96T
EUR 648

BMP-7 (human) ELISA Kit

K4749-100 100 assays
EUR 809
Description: Sensitive, Colorimetric Assay

Human BMP-7 PicoKine ELISA Kit

EK0884 96 wells
EUR 456
Description: For quantitative detection of human BMP-7 in bone tissue, cell culture supernates, serum, plasma((heparin, EDTA) and urine.

Human BMP-7 Antibody (Biotin Conjugate)

32701-05121 150 ug
EUR 369

BMP-7 ELISA Kit (Human) (OKBB00356)

OKBB00356 96 Tests
EUR 544
Description: Description of target: Bone morphogenetic protein 7 or BMP7 (also known as osteogenic protein-1 or OP-1) is a protein that in humans is encoded by the BMP7 gene.The protein encoded by this gene is a member of the TGF-β superfamily. Like other members of the bone morphogenetic protein family of proteins, it plays a key role in the transformation of mesenchymal cells into bone and cartilage. It is inhibited by noggin and a similar protein, chordin, which are expressed in the Spemann-Mangold Organizer. BMP7 may be involved in bone homeostasis. It is expressed in the brain, kidneys and bladder.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 10 pg/ml

ELISA kit for Human BMP-7

EK5396 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Human BMP-7 in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Mouse BMP-7

EK5674 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse BMP-7 in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Rat BMP-7

EK5675 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Rat BMP-7 in samples from serum, plasma, tissue homogenates and other biological fluids.

BMP-12/GDF-7, human recombinant

4572-100
EUR 615

BMP-12/GDF-7, human recombinant

4572-1000
EUR 4220

BMP-12/GDF-7, human recombinant

4572-20
EUR 278

Rat Bone morphogenetic protein 7(BMP-7)ELISA Kit

GA-E0275RT-48T 48T
EUR 317

Rat Bone morphogenetic protein 7(BMP-7)ELISA Kit

GA-E0275RT-96T 96T
EUR 496

Human Bone Morphogenetic Protein 7 (BMP-7) CLIA Kit

abx195271-96tests 96 tests
EUR 825

Mouse Bone Morphogenetic Protein 7 (BMP-7) CLIA Kit

abx195272-96tests 96 tests
EUR 825

Rat Bone Morphogenetic Protein 7 (BMP-7) CLIA Kit

abx195273-96tests 96 tests
EUR 825

BMP-7 Bone Morphogenetic Protein-7 Human Recombinant Protein

PROTP18075-3 Regular: 10ug
EUR 317
Description: Bone Morphogenetic Protein-7 Human Recombinant produced in E.Coli is a monomeric, non-glycosylated, polypeptide chain containing 139 amino acids and having a molecular mass of 15679.97 Dalton. ;The BMP-7 is purified by proprietary chromatographic techniques.

Rat BMP-7(Bone Morphogenetic Protein 7) ELISA Kit

ER0772 96T
EUR 476.25
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 9.375pg/ml

Mouse BMP-7(Bone morphogenetic protein 7) ELISA Kit

EM0224 96T
EUR 476.25
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 9.375pg/ml

Bovine BMP-7(Bone morphogenetic protein 7) ELISA Kit

EB0155 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Cattle;Sensitivity: 18.75pg/ml

Human BMP-7(Bone Morphogenetic Protein 7) ELISA Kit

EH0048 96T
EUR 476.25
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Human Bone morphogenetic protein 7, BMP-7 ELISA Kit

CSB-E08122h-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Human Bone morphogenetic protein 7, BMP-7 in samples from serum, plasma, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Bone morphogenetic protein 7, BMP-7 ELISA Kit

1-CSB-E08122h
  • EUR 602.00
  • EUR 4238.00
  • EUR 2256.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Bone morphogenetic protein 7, BMP-7 in samples from serum, plasma, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Bone morphogenetic protein 7, BMP-7 ELISA Kit

CSB-E08125m-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Mouse Bone morphogenetic protein 7, BMP-7 in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Bone morphogenetic protein 7, BMP-7 ELISA Kit

1-CSB-E08125m
  • EUR 767.00
  • EUR 5089.00
  • EUR 2699.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Bone morphogenetic protein 7, BMP-7 in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat Bone morphogenetic protein 7(BMP-7)ELISA Kit

QY-E11377 96T
EUR 361

Mouse Bone morphogenetic protein 7(BMP-7)ELISA Kit

QY-E20211 96T
EUR 361

Rat Bone morphogenetic protein 7,BMP-7 ELISA Kit

CN-01917R1 96T
EUR 468

Mouse Bone morphogenetic protein 7,BMP-7 ELISA Kit

CN-02796M1 96T
EUR 467

Mouse Bone morphogenetic protein 7,BMP-7 ELISA Kit

CN-02796M2 48T
EUR 316

Human Bone morphogenetic protein 7,BMP-7 ELISA Kit

CN-03996H1 96T
EUR 489

Human Bone morphogenetic protein 7,BMP-7 ELISA Kit

CN-03996H2 48T
EUR 338

ELISA kit for Porcine BMP-7 (Bone Morphogenetic Protein 7)

E-EL-P0199 1 plate of 96 wells
EUR 520
Description: A sandwich ELISA kit for quantitative measurement of Porcine BMP-7 (Bone Morphogenetic Protein 7) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Rat BMP-7 (Bone Morphogenetic Protein 7)

E-EL-R0119 1 plate of 96 wells
EUR 377
Description: A sandwich ELISA kit for quantitative measurement of Rat BMP-7 (Bone Morphogenetic Protein 7) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Mouse BMP-7 (Bone Morphogenetic Protein 7)

E-CL-M0144 1 plate of 96 wells
EUR 584
Description: A sandwich CLIA kit for quantitative measurement of Mouse BMP-7 (Bone Morphogenetic Protein 7) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Rat BMP-7 (Bone Morphogenetic Protein 7)

E-CL-R0085 1 plate of 96 wells
EUR 584
Description: A sandwich CLIA kit for quantitative measurement of Rat BMP-7 (Bone Morphogenetic Protein 7) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human BMP-7 (Bone Morphogenetic Protein 7)

E-EL-H0013 1 plate of 96 wells
EUR 377
Description: A sandwich ELISA kit for quantitative measurement of Human BMP-7 (Bone Morphogenetic Protein 7) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Mouse BMP-7 (Bone Morphogenetic Protein 7)

E-EL-M0196 1 plate of 96 wells
EUR 377
Description: A sandwich ELISA kit for quantitative measurement of Mouse BMP-7 (Bone Morphogenetic Protein 7) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Human BMP-7 (Bone Morphogenetic Protein 7)

E-CL-H0013 1 plate of 96 wells
EUR 584
Description: A sandwich CLIA kit for quantitative measurement of Human BMP-7 (Bone Morphogenetic Protein 7) in samples from Serum, Plasma, Cell supernatant

BMP-7 Bone Morphogenetic Protein-7 Human Recombinant Protein, Plant

PROTP18075 Regular: 10ug
EUR 317
Description: Bone Morphogenetic Protein-7 Human Recombinant produced in Plant is a monomeric, glycosylated, polypeptide chain containing 144 amino acids and having a molecular mass of 16.5kDa, and fused to a 6xHis-tag at the N-terminus. ;The BMP-7 is purified by proprietary chromatographic techniques.

BMP-7 Bone Morphogenetic protein-7 Human Recombinant Protein, HEK

PROTP18075-1 Regular: 5ug
EUR 317
Description: BMP-7 Human Recombinant produced in HEK cells is a glycosylated disulfide-linked homodimer, having a molecular weight range of 30-38kDa due to glycosylation.;The BMP7 corresponds to amino acid residues 315 to 431 of the full-length BMP-7 precursor and is purified by proprietary chromatographic techniques.

BMP-7 Bone Morphogenetic Protein-7 Human Recombinant Protein, CHO

PROTP18075-2 Regular: 10ug
EUR 317
Description: N-TERMINAL---Human BMP-2 (Met the signal peptide and propetide contains 139 amino acid residues. The glycosylation of BMP-7 increases the molecular mass and the glycosylated proteins migrate as 25 ~ 40 kDa in SDS-PAGE under non-reducing conditions. ;BMP-7 is purified by proprietary chromatographic techniques.

Rabbit Anti Human Bmp-7 Polyclonal Antibody

CPBT-65603RH 1 ml
EUR 819

Human BMP-7 AssayLite Antibody (FITC Conjugate)

32701-05141 150 ug
EUR 428

Human BMP-7 AssayLite Antibody (RPE Conjugate)

32701-05151 150 ug
EUR 428

Human BMP-7 AssayLite Antibody (APC Conjugate)

32701-05161 150 ug
EUR 428

Human BMP-7 AssayLite Antibody (PerCP Conjugate)

32701-05171 150 ug
EUR 471

Human CellExp™ BMP-7, Human Recombinant

6446-10 Ask for price

Human CellExp™ BMP-7, Human Recombinant

6446-50 Ask for price

BMP-7 Bone Morphogenetic Protein-7 Human Recombinant Protein, His Tag

PROTP18075-4 Regular: 50ug
EUR 317
Description: BMP7 Human Recombinant produced in E.Coli is a monomeric, non-glycosylated, polypeptide chain containing 148 amino acids (293-431) and having a molecular mass of 16.8 kDa. ;The BMP-7 is fused to 8 amino acid His Tag at C-terminus & purified by proprietary chromatographic techniques.

BMP-7 ELISA Kit| Rat Bone Morphogenetic Protein 7 ELISA Kit

EF017571 96 Tests
EUR 689

BMP-7 ELISA Kit| Mouse Bone morphogenetic protein 7 ELISA Kit

EF012943 96 Tests
EUR 689

Chinese Hamster BMP-7 PicoKine™ ELISA Kit

EK1443-HA 96 wells
EUR 425
Description: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Chinese hamster BMP-7. 96wells/kit, with removable strips.

Rabbit Anti Human Bmp-7 Polyclonal Antibody,Biotin

CPBT-65604RH 50 µg
EUR 881

BMP-7 ELISA Kit (Human) : 96 Wells (OKAG00199)

OKAG00199 96 Wells
EUR 596
Description: Description of target: This gene encodes a member of the transforming growth factor-beta (TGF-beta) family of proteins. The encoded preproprotein is proteolytically processed to generate each subunit of the mature homodimer, which plays a role in bone, kidney and brown adipose tissue development. This protein induces ectopic bone formation and may promote fracture healing in human patients.;Species reactivity: Human;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 63 pg/mL

Anti-Cytokeratin 7

DB051RTU-7 7 ml
EUR 204
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Human Bone Morphogenic Protein 7 (BMP-7) ELISA Kit, 96 tests, Quantitative

100-190-B7H 1 Kit
EUR 834

Rat Bone morphogenetic protein 7,BMP-8 ELISA Kit

CN-01917R2 48T
EUR 318

Recombinant Human Galectin-7

7-00442 2µg Ask for price

Recombinant Human Galectin-7

7-00443 10µg Ask for price

Recombinant Human Galectin-7

7-00444 1mg Ask for price

Recombinant Human Interleukin-7

7-00895 2µg Ask for price

Recombinant Human Interleukin-7

7-00896 10µg Ask for price

Recombinant Human Interleukin-7

7-00897 1mg Ask for price

Recombinant Mouse Interleukin-7

7-00904 2µg Ask for price

Recombinant Mouse Interleukin-7

7-00905 10µg Ask for price

Recombinant Mouse Interleukin-7

7-00906 1mg Ask for price

Recombinant Human Kallikrein-7

7-03034 2µg Ask for price

Recombinant Human Kallikrein-7

7-03035 10µg Ask for price

Recombinant Human Kallikrein-7

7-03036 100µg Ask for price

Nine hundred and fifty-four participants (average age 55 years, 52% men) have information available in pulse oximetry and cardiometabolic risk markers. average oxyhemoglobin saturation was 90% (interquartile range 88% -92%) and 43 (4.5%) had excessive erythrocytosis. older age, decreased lung function height-adjustable, and a higher body mass index (BMI) is associated with having ≤85% oxyhemoglobin saturation.