Cross-Sectional Comparison of Sleep-Disordered Breathing in Native Peruvian Highlanders and Lowlanders.

Pham, V. Luu, Christopher Meinzen, Rafael S. Arias, Noah G. Schwartz, Adi Rattner, Catherine H. Miele, Philip L. Smith, Hartmut Schneider, J. Jaime Miranda, Robert H. Gilman, Vsevolod Y. Polotsky, William Checkley, and Alan R. Schwartz. comparative cross-sectional study of sleep-disordered breathing in the original Peruvian highlands and lowlands. High Alt Med Biol. 18: 11-19, 2017.


BACKGROUND
Altitude can highlight irregular sleep breathing (SDB), which has been associated with cardiovascular and metabolic diseases. SDB on the plateau is not marked in large controlled studies. The purpose of this study was to compare the prevalence and severity of SDB in the highlands and lowlands.


METHOD
170 age, body-mass Index, (BMI), and gender couples (age 58.2 ± 12.4 years, BMI 27.2 ± 3.5 kg / m2, and 86 male and 84 female) from Crónicas Cohort Study recruited at sea level (Lima) and high altitude (Puno, 3825 m) arrangements in Peru. Participants underwent nocturnal polygraph simultaneously and actigraphy to characterize patterns of breathing, movement arousals, and sleep / wake state. We compared the prevalence of SDB, type, and severity between the highlands and lowlands as measured by the apnea-hypopnea index (AHI) and pulse oximetry (SpO2) during sleep.


RESULTS
Greater prevalence of sleep apnea in the highlands than in the lowlands (77% vs 54%, p <0.001). Compared with the lowlands, highlands have a two-fold increase in AHI due to the increase in the central rather than obstructive apnea. On the plateau compared with the lowlands, lower SpO2 during wakefulness and a further decrease during sleep (p <0.001). Hypoxemia during wakefulness predict sleep apnea in the highlands, and it seems to mediate the effects of altitude on the prevalence of sleep apnea. Surprisingly, hypoxemia also quite common in the lowlands, and it is also associated with an increased likelihood of sleep apnea.


CONCLUSION
high altitude and hypoxemia at both high and low altitudes associated with an increased prevalence and severity of SDB. Our findings show that most of the highlands remain at risk for SDB sequelae.

 Cross-Sectional Comparison of Sleep-Disordered Breathing in Native Peruvian Highlanders and Lowlanders.
Cross-Sectional Comparison of Sleep-Disordered Breathing in Native Peruvian Highlanders and Lowlanders.

Increased Cardiometabolic Risk and Worsening hypoxemia at High Altitude.

Miele, Catherine H., Alan R. Schwartz, Robert H. Gilman, Luu Pham, Robert A. Wise, Victor G. Davila-Roman, Jonathan C. June, Vsevolod Y. Polotsky, J. Jaime Miranda, Fabiola Leon-Velarde and William Checkley. Increased risk of cardiometabolic and worsening hypoxemia at high altitude. High Alt Med Biol. 17: 93-100 syndrome, 2016.-Metabolic, insulin resistance, diabetes, and dyslipidemia associated with an increased risk of cardiovascular disease.

While excessive erythrocytosis is associated with cardiovascular complications, it is not clear how the worsening hypoxemia of any level affecting cardiometabolic risk factors in a population of high altitude. We studied the relationship between lunch break oxyhemoglobin saturation and cardiometabolic risk factors in adult participants who stay in Puno, Peru (3825 m asl). We used multivariable logistic regression model to study the relationship between having a lower oxyhemoglobin saturation and cardiometabolic risk markers.

BMP-7

MO15079 500 ug
EUR 1092

BMP-7

PR27026-B each
EUR 184.5

BMP-7 CHO

PR27001 2 ug
EUR 229.2

BMP-7, Human

E34M068H 5 μg
EUR 155

BMP-7, Human

HY-P7008 50ug
EUR 734.4

Human BMP-7

MBS691622-0002mg 0.002mg
EUR 300

Human BMP-7

MBS691622-001mg 0.01mg
EUR 450

Human BMP-7

MBS691622-5x001mg 5x0.01mg
EUR 1725

BMP-7, Human

MBS8575225-0005mg 0.005mg
EUR 245

BMP-7, Human

MBS8575225-5x0005mg 5x0.005mg
EUR 940

BMP-7 ELISA

MBS494756-5x96Tests 5x96Tests
EUR 4145

BMP-7 ELISA

MBS494756-96Tests 96Tests
EUR 900

BMP-7 Antibody

E301185 100ug/200ul
EUR 275
Description: Available in various conjugation types.

BMP-7 Antibody

5677-100 each
EUR 430.8

BMP-7 Antibody

5677R-100 each
EUR 379.2

BMP-7 Antibody

5677R-30T each
EUR 175.2

BMP-7 Antibody

GWB-5B4980 1 ml Ask for price

BMP-7 Antibody

GWB-CF1347 0.05 mg Ask for price

BMP-7 Antibody

MBS853509-01mg 0.1mg
EUR 345

BMP-7 Antibody

MBS853509-01mLAF405L 0.1mL(AF405L)
EUR 565

BMP-7 Antibody

MBS853509-01mLAF405S 0.1mL(AF405S)
EUR 565

BMP-7 Antibody

MBS853509-01mLAF610 0.1mL(AF610)
EUR 565

BMP-7 Antibody

MBS853509-01mLAF635 0.1mL(AF635)
EUR 565

BMP-7 Antibody

MBS9508730-005mL 0.05mL
EUR 285

BMP-7 Antibody

MBS9508730-01mL 0.1mL
EUR 385

BMP-7 Antibody

MBS9508730-5x01mL 5x0.1mL
EUR 1590

BMP-7 Antibody

R12-2039-100ul 100μl
EUR 217
Description: BMP-7 Rabbit Polyclonal Antibody

BMP-7 Antibody

R12-2039-50ul 50μl
EUR 143.5
Description: BMP-7 Rabbit Polyclonal Antibody

BMP 7 antibody

20R-1847 100 ug
EUR 807.6
Description: Rabbit polyclonal BMP 7 antibody

BMP 7 antibody

20R-1848 100 ug
EUR 781.2
Description: Goat polyclonal BMP 7 antibody

Anti-Human BMP-7

GWB-BIG3BE 500ug Ask for price

Anti-Human BMP-7

MBS550661-01mg 0.1mg
EUR 260

Anti-Human BMP-7

MBS550661-02mg 0.2mg
EUR 335

Human BMP-7 Antibody

32701-05111 150 ug
EUR 215

BMP-7 Antibody (Biotin)

GWB-615F20 0.05 mg Ask for price

BMP-7, human recombinant

4579-10 each
EUR 307.2

BMP-7, human recombinant

4579-1000 each
EUR 5475.6

BMP-7, human recombinant

4579-50 each
EUR 738

Recombinant Human BMP-7

HEOPP-0210 10ug Ask for price

Recombinant Human BMP-7

P1157-.01 10ug
EUR 272.8
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Human BMP-7

P1157-.1 100ug
EUR 1561.6
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Human BMP-7

P1157-.5 500ug
EUR 3503.2
Description: Peptides & Proteins|Recombinant Proteins

BMP-7 Polyclonal Antibody

ABP50780-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of BMP-7 from Human, Mouse, Rat. This BMP-7 antibody is for WB , IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human BMP-7

BMP-7 Polyclonal Antibody

ABP50780-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of BMP-7 from Human, Mouse, Rat. This BMP-7 antibody is for WB , IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human BMP-7

BMP-7 Polyclonal Antibody

ABP50780-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of BMP-7 from Human, Mouse, Rat. This BMP-7 antibody is for WB , IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human BMP-7

BMP-7 Polyclonal Antibody

40651 100ul
EUR 319

BMP-7 Polyclonal Antibody

40651-100ul 100ul
EUR 302.4

BMP-7 Polyclonal Antibody

40651-50ul 50ul
EUR 224.4

BMP-7 Recombinant Protein

40-641 2 ug
EUR 311.1
Description: TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth, and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling, and maintenance of a variety of other tissues and organs. BMP-7, also known as osteogenic protein-1 or OP-1, is a potent bone inducing agent, which in the presence of an appropriate osteoconductive carrier (e.g. collagen sponge or synthetic hydroxyapatite) can be used in the treatment of bone defects. A bone-graft substitute, called OP-1TM implant, made of recombinant human BMP-7 associated with bovine bone-derived collagen, has recently been approved by the FDA as a device for treating critical-size bone fractures. The potential use of BMP-7 in dental reconstructive surgeries is currently under investigation. Recombinant Human BMP-7 is a 28.8 kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 315 to 431 of the full-length BMP-7 precursor.

BMP-7 Recombinant Protein

40-642 2 ug
EUR 311.1
Description: TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth, and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling, and maintenance of a variety of other tissues and organs. BMP-7, also known as osteogenic protein-1 or OP-1, is a potent bone inducing agent, which in the presence of an appropriate osteoconductive carrier (e.g. collagen sponge or synthetic hydroxyapatite) can be used in the treatment of bone defects. A bone-graft substitute, called OP-1TM implant, made of recombinant human BMP-7 associated with bovine bone-derived collagen, has recently been approved by the FDA as a device for treating critical-size bone fractures. The potential use of BMP-7 in dental reconstructive surgeries is currently under investigation. Recombinant Human BMP-7 is a homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 315 to 431 of the full-length BMP-7 precursor. Recombinant Human BMP-7 has a calculated molecular weight of 26.4 kDa; however, due to glycosylation, the BMP-7 homodimer migrates at an apparent molecular weight of approximately 25-35 kDa by SDS-PAGE analysis under non-reducing conditions.

BMP-7 Polyclonal Antibody

E040651 100μg/100μl
EUR 255
Description: Available in various conjugation types.

BMP-7 Polyclonal Antibody

E20-70503 100ug
EUR 225
Description: Available in various conjugation types.

BMP-7 Polyclonal Antibody

E44H01673 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

BMP-7 Polyclonal Antibody

E-AB-40594-100uL 100uL
EUR 230
Description: Unconjugated

BMP-7 Polyclonal Antibody

E-AB-40594-200uL 200uL
EUR 380
Description: Unconjugated

BMP-7 Polyclonal Antibody

E-AB-40594-20uL 20uL
EUR 65
Description: Unconjugated

BMP-7 Polyclonal Antibody

E-AB-40594-50uL 50uL
EUR 125
Description: Unconjugated

BMP-7 Polyclonal Antibody

BT-AP00930-100ul 100ul Ask for price
Description: BMP7 encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients.

BMP-7 Polyclonal Antibody

BT-AP00930-20ul 20ul Ask for price
Description: BMP7 encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients.

BMP-7 Polyclonal Antibody

BT-AP00930-50ul 50ul Ask for price
Description: BMP7 encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients.

BMP-7 Polyclonal Antibody

MBS9242832-01mL 0.1mL
EUR 415

BMP-7 Polyclonal Antibody

MBS9242832-5x01mL 5x0.1mL
EUR 1841

BMP-7 Polyclonal Antibody

MBS9405868-005mL 0.05mL
EUR 245

BMP-7 Polyclonal Antibody

MBS9405868-01mL 0.1mL
EUR 305

BMP-7 Polyclonal Antibody

MBS9405868-5x01mL 5x0.1mL
EUR 1230

BMP-7 Polyclonal Antibody

MBS8521484-01mg 0.1mg
EUR 305

BMP-7 Polyclonal Antibody

MBS8521484-01mLAF405L 0.1mL(AF405L)
EUR 465

BMP-7 Polyclonal Antibody

MBS8521484-01mLAF405S 0.1mL(AF405S)
EUR 465

BMP-7 Polyclonal Antibody

MBS8521484-01mLAF610 0.1mL(AF610)
EUR 465

BMP-7 Polyclonal Antibody

MBS8521484-01mLAF635 0.1mL(AF635)
EUR 465

BMP-7 Polyclonal Antibody

MBS2537707-002mL 0.02mL
EUR 140

BMP-7 Polyclonal Antibody

MBS2537707-006mL 0.06mL
EUR 180

BMP-7 Polyclonal Antibody

MBS2537707-012mL 0.12mL
EUR 260

BMP-7 Polyclonal Antibody

MBS2537707-02mL 0.2mL
EUR 405

BMP-7 Polyclonal Antibody

MBS2537707-5x02mL 5x0.2mL
EUR 1725

Rat BMP-7 ELISA Kit

EK5675 96 tests
EUR 599

Rat BMP-7 ELISA Kit

EF017571 96tests
EUR 566

Human BMP-7 ELISA Kit

E16HE0182 96T
EUR 1000

BMP-7 (Human) ELISA Kit

EKA52015-5x96T 5x96T Ask for price

BMP-7 (Human) ELISA Kit

EKA52015-96T 96T
EUR 446.9

Human BMP-7 ELISA KIT

E42EH-58 96T/48T Ask for price

Human BMP-7 ELISA Kit

E28L0440 96T
EUR 666.67

Human BMP-7 ELISA Kit

EK5396 96 tests
EUR 599

Mouse BMP-7 ELISA Kit

EK5674 96 tests
EUR 599

Human BMP-7 ELISA KIT

EF000036 96tests
EUR 566

Mouse BMP-7 ELISA Kit

EF012943 96tests
EUR 566

Human BMP-7 ELISA Kit

GWB-SKR199 96 Tests Ask for price

BMP-7 (human) ELISA Kit

K4749-100 100 assays
EUR 970.8
Description: Sensitive, Colorimetric Assay

Human BMP-7 ELISA Kit

LF-EK50940 1×96T
EUR 777.6

BMP-7 Human ELISA Kit

MBS355414-5x96Tests 5x96Tests
EUR 2750

BMP-7 Human ELISA Kit

MBS355414-96Tests 96Tests
EUR 610

RABBIT ANTI HUMAN BMP-7

MBS220694-1mL 1mL
EUR 455

RABBIT ANTI HUMAN BMP-7

MBS220694-5x1mL 5x1mL
EUR 1870

RABBIT ANTI HUMAN BMP-7

MBS221842-005mg 0.05mg
EUR 455

RABBIT ANTI HUMAN BMP-7

MBS221842-5x005mg 5x0.05mg
EUR 1870

Mouse Anti-Human BMP-7

MBS690608-05mg 0.5mg
EUR 525

Mouse Anti-Human BMP-7

MBS690608-5x05mg 5x0.5mg
EUR 2080

Rabbit Anti-Human BMP-7

102-PA92 100ug
EUR 240

Anti-Human BMP-7 Antibody

101-M149 100 µg
EUR 399
Description: Bone morphogenetic protein 7 (BMP7), also known as osteogenic protein 1 (OP1), is a widely expressed TGFβ superfamily member with important functions during embryogenesis, in the adult, and in disease. Human BMP7 is synthesized with a 29 amino acid (aa) signal sequence, a 263 aa propeptide, and a 139 aa growth factor domain. The growth factor domain of human BMP7 shares 98% aa sequence identity with mouse and rat BMP7. The BMP7 propeptide is cleaved intracellularly but often remains associated with the mature Cterminus. Based on in vivo and in vitro studies, BMP 7 has the potential to be secreted as a disulfidelinked mature homodimer, or particularly as a heteromeric complex that consists of two propeptides noncovalently associated with a mature disulfidelinked homodimer. The presence of the propeptides in BMP7 appears to stabilize the molecule and provide a docking mechanism for extracellular storage on molecules such as fibrillin 1 and 2 . The propeptides themselves do not impart latency to the complex. BMP7 binding to type II receptors rapidly displaces the prodomain:mature molecule interaction and has no effect on activity. But it is suggested that immobilized BMP7 (via prodomain:fibrillin) is inactive, allowing for possible longterm storage of the molecule. BMP 7 interacts with the type 2 receptors Activin RIIA, Activin RIIB, and BMPRII and the type 1 receptors Activin RIA, BMPRIA, and BMPRIB. BMP7 may also be processed into a disulfidelinked heterodimer with either BMP2 or BMP4. Such complexes may show increased potency and range of activity compared to BMP7 homodimers. BMP7 plays a role in a variety of organ systems. It promotes new bone formation and nephron development (10, 11), inhibits the branching of prostate epithelium (12), and antagonizes epithelialmesenchymal transition (EMT).

Anti-Human BMP-7 Antibody

101-M167 500 µg
EUR 244.65
Description: TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. BMP-7, also known as osteogenic protein-1 or OP-1, is a potent bone inducing agent, which in the presence of appropriate osteoconductive carrier (e.g. collagen sponge or synthetic hydroxyapatite) can be used in the treatment of bone defects. A bone-graft substitute, called OP-1TM implant, made of recombinant human BMP-7 associated with bovine bone-derived collagen, has recently been approved by the FDA as a device for treating critical-size bone fractures. The potential use of BMP-7 in dental reconstructive surgeries is currently under investigation. Recombinant human BMP-7 is a 28.8 kDa homodimeric glycoprotein consisting of two 116 amino acid subunits, which correspond to amino acid residues 316 to 431 of the full-length BMP-7 precursor.

Anti-Human BMP-7 Antibody

101-M238 100 µg
EUR 399
Description: Bone morphogenetic protein 7 (BMP7), also known as osteogenic protein 1 (OP1), is a widely expressed TGFβ superfamily member with important functions during embryogenesis, in the adult, and in disease. Human BMP7 is synthesized with a 29 amino acid (aa) signal sequence, a 263 aa propeptide, and a 139 aa growth factor domain. The growth factor domain of human BMP7 shares 98% aa sequence identity with mouse and rat BMP7. The BMP7 propeptide is cleaved intracellularly but often remains associated with the mature Cterminus. Based on in vivo and in vitro studies, BMP 7 has the potential to be secreted as a disulfidelinked mature homodimer, or particularly as a heteromeric complex that consists of two propeptides noncovalently associated with a mature disulfidelinked homodimer. The presence of the propeptides in BMP7 appears to stabilize the molecule and provide a docking mechanism for extracellular storage on molecules such as fibrillin 1 and 2 . The propeptides themselves do not impart latency to the complex. BMP7 binding to type II receptors rapidly displaces the prodomain:mature molecule interaction and has no effect on activity. But it is suggested that immobilized BMP7 (via prodomain:fibrillin) is inactive, allowing for possible longterm storage of the molecule. BMP 7 interacts with the type 2 receptors Activin RIIA, Activin RIIB, and BMPRII and the type 1 receptors Activin RIA, BMPRIA, and BMPRIB. BMP7 may also be processed into a disulfidelinked heterodimer with either BMP2 or BMP4. Such complexes may show increased potency and range of activity compared to BMP7 homodimers. BMP7 plays a role in a variety of organ systems. It promotes new bone formation and nephron development (10, 11), inhibits the branching of prostate epithelium (12), and antagonizes epithelialmesenchymal transition (EMT).

Anti-Human BMP-7 Antibody

102-P105 100 µg
EUR 245.7
Description: TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. BMP-7, also known as osteogenic protein-1 or OP-1, is a potent bone inducing agent, which in the presence of appropriate osteoconductive carrier (e.g. collagen sponge or synthetic hydroxyapatite) can be used in the treatment of bone defects. A bone-graft substitute, called OP-1TM implant, made of recombinant human BMP-7 associated with bovine bone-derived collagen, has recently been approved by the FDA as a device for treating critical-size bone fractures. The potential use of BMP-7 in dental reconstructive surgeries is currently under investigation. Recombinant human BMP-7 is a 28.8 kDa homodimeric glycoprotein consisting of two 116 amino acid subunits, which correspond to amino acid residues 316 to 431 of the full-length BMP-7 precursor.

Anti-Human BMP-7 Antibody

102-PA92S 100 µg
EUR 126
Description: Bone morphogenetic protein 7 (BMP-7), also known as osteogenic protein 1 (OP1), is a widely expressed TGFβ superfamily member with important functions during embryogenesis, in the adult, and in disease. Human BMP-7 is synthesized with a 29 amino acid (aa) signal sequence, a 263 aa propeptide, and a 139 aa growth factor domain. The growth factor domain of human BMP-7 shares 98% aa sequence identity with mouse and rat BMP-7. The BMP-7 propeptide is cleaved intracellularly but often remains associated with the mature C-terminus. Based on in vivo and in vitro studies, BMP-7 has the potential to be secreted as a disulfide-linked mature homodimer, or particularly as a heteromeric complex that consists of two propeptides noncovalently associated with a mature disulfide linked homodimer. The presence of the propeptides in BMP-7 appears to stabilize the molecule and provide a docking mechanism for extracellular storage on molecules such as fibrillin1 and 2. The propeptides themselves do not impart latency to the complex. BMP-7 binding to type II receptors rapidly displaces the prodomain: mature molecule interaction and has no effect on activity.BMP-7 plays a role in a variety of organ systems. It promotes new bone formation and nephron development, inhibits the branching of prostate epithelium, and antagonizes epithelial mesenchymal transition (EMT). In pathological conditions, BMP-7 inhibits tumor growth and metastasis, ameliorates fibrotic damage in nephritis, and promotes neuro regeneration following brain ischemia.

BMP-7 (E173) polyclonal antibody

E43S3674 100ul
EUR 225
Description: Available in various conjugation types.

OAPA00163-5UG - BMP-7 Antibody

OAPA00163-5UG 5ug
EUR 69

Human BMP-7 Recombinant Protein

100-328 10 µg
EUR 196.35
Description: TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. BMP-7, also known as osteogenic protein-1 or OP-1, is a potent bone inducing agent, which in the presence of appropriate osteoconductive carrier (e.g. collagen sponge or synthetic hydroxyapatite) can be used in the treatment of bone defects. A bone-graft substitute, called OP-1TM implant, made of recombinant human BMP-7 associated with bovine bone-derived collagen, has recently been approved by the FDA as a device for treating critical-size bone fractures. The potential use of BMP-7 in dental reconstructive surgeries is currently under investigation. Recombinant human BMP-7 is a homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 315 to 431 of the full-length BMP 7 precursor. Recombinant human BMP-7 has a calculated molecular weight of 26.4 kDa; however, due to glycosylation, the BMP-7 homodimer migrates at an apparent molecular weight of approx. 25-35 kDa by SDS-PAGE analysis under non-reducing conditions.

Human BMP-7 Recombinant Protein

100-328S 2 µg
EUR 92.4
Description: TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. BMP-7, also known as osteogenic protein-1 or OP-1, is a potent bone inducing agent, which in the presence of appropriate osteoconductive carrier (e.g. collagen sponge or synthetic hydroxyapatite) can be used in the treatment of bone defects. A bone-graft substitute, called OP-1TM implant, made of recombinant human BMP-7 associated with bovine bone-derived collagen, has recently been approved by the FDA as a device for treating critical-size bone fractures. The potential use of BMP-7 in dental reconstructive surgeries is currently under investigation. Recombinant human BMP-7 is a homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 315 to 431 of the full-length BMP 7 precursor. Recombinant human BMP-7 has a calculated molecular weight of 26.4 kDa; however, due to glycosylation, the BMP-7 homodimer migrates at an apparent molecular weight of approx. 25-35 kDa by SDS-PAGE analysis under non-reducing conditions.

Recombinant Human BMP-7 Protein

RP02513 20μg
EUR 520

Recombinant Human BMP-7 protein

CD02239-10ug 10ug
EUR 409
Description: Bone Morphogenetic Protein 7 is one of the BMPs, some of which belong to the TGF-beta superfamily (BMP2-7). There are more than thirteen BMPs have been discovered nowadays and they are involved in inducing cartilage and bone formation. BMP-7 is mainly expressed in kidney and bladder. It is also present in developing eyes, brain and ear during embryogenesis. BMP-7 also named osteogenic protein-1 (OP-1) is a potent osteoinductive cytokine and plays role in osteoblast differentiation, SMAD1 production and renal development and repair. Human BMP-7 is synthesized with a signal sequence (29 a.a.), a propeptide (263 a.a.), and a growth factor domain (139 a.a.). The growth factor domain of human BMP-7 shares 98 % a.a. sequence identity with mouse and rat BMP-7.

Recombinant Human BMP-7 protein

CD02239-2ug 2ug
EUR 176
Description: Bone Morphogenetic Protein 7 is one of the BMPs, some of which belong to the TGF-beta superfamily (BMP2-7). There are more than thirteen BMPs have been discovered nowadays and they are involved in inducing cartilage and bone formation. BMP-7 is mainly expressed in kidney and bladder. It is also present in developing eyes, brain and ear during embryogenesis. BMP-7 also named osteogenic protein-1 (OP-1) is a potent osteoinductive cytokine and plays role in osteoblast differentiation, SMAD1 production and renal development and repair. Human BMP-7 is synthesized with a signal sequence (29 a.a.), a propeptide (263 a.a.), and a growth factor domain (139 a.a.). The growth factor domain of human BMP-7 shares 98 % a.a. sequence identity with mouse and rat BMP-7.

BMP-7, Recombinant Human Protein

MBS480575-001mg 0.01mg
EUR 570

BMP-7, Recombinant Human Protein

MBS480575-5x001mg 5x0.01mg
EUR 2500

BMP-7 Rabbit Polyclonal Antibody

ES1779-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against BMP-7 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

BMP-7 Rabbit Polyclonal Antibody

ES1779-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against BMP-7 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

BMP-7 Polyclonal Conjugated Antibody

C40651 100ul
EUR 476.4

BMP-7 Polyclonal Conjugated Antibody

MBS9449657-01mLAF350 0.1mL(AF350)
EUR 480

BMP-7 Polyclonal Conjugated Antibody

MBS9449657-01mLAF405 0.1mL(AF405)
EUR 480

BMP-7 Polyclonal Conjugated Antibody

MBS9449657-01mLAF488 0.1mL(AF488)
EUR 480

BMP-7 Polyclonal Conjugated Antibody

MBS9449657-01mLAF555 0.1mL(AF555)
EUR 480

BMP-7 Polyclonal Conjugated Antibody

MBS9449657-01mLBiotin 0.1mL(Biotin)
EUR 480

BMP-7, Bone Morphogenetic Protein-7, human

RC219-18 2ug
EUR 125.26

Bone Morphogenetic Protein 7 (BMP-7) Antibody

abx411168-1ml 1 ml
EUR 610.8

Bone Morphogenetic Protein 7 (BMP-7) Antibody

abx412613-50ug 50 ug
EUR 610.8

Bone Morphogenetic Protein 7 (BMP-7) Antibody

abx412613-1ml 1 ml
EUR 425

Bone Morphogenetic Protein 7 (BMP-7) Antibody

abx411168-100g 100 µg
EUR 425

Rat BMP- 7 ELISA Kit

ELA-E0799r 96tests
EUR 756

Nine hundred and fifty-four participants (average age 55 years, 52% men) have information available in pulse oximetry and cardiometabolic risk markers. average oxyhemoglobin saturation was 90% (interquartile range 88% -92%) and 43 (4.5%) had excessive erythrocytosis. older age, decreased lung function height-adjustable, and a higher body mass index (BMI) is associated with having ≤85% oxyhemoglobin saturation.