Healy, Katherine, Alain B. Labrique, J. Jaime Miranda, Robert H. Gilman, David Danz, Victor G. Davila-Roman, Luis Huicho, Fabiola León-Velarde, and William Checkley. dark adaptation at high altitude: Unexpected pupillary response to chronic hypoxia in the Andean highlands. High Alt Med Biol. 17: 208-213 mountain sickness, chronic-2016 is a maladaptive response to the high altitude (> 2500 m above sea level) and is characterized by excessive erythrocytosis and hypoxemia resulting from long-term hypobaric hypoxia.
No known early predictor of chronic mountain sickness and the diagnosis is based on the presence of excessive erythrocytosis and clinical features. Impaired dark adaptation, or the inability to visually adjust from high to low-light settings, occurs in response to mild hypoxia and can serve as an early predictor of hypoxemia and chronic mountain sickness. We aimed to evaluate the relationship between pupillary response assessed by adaptometry dark and daytime hypoxemia high Andean population aged ≥35 years living in Puno, Peru. Oxyhemoglobin saturation (SpO2) were recorded using a handheld pulse oximeter.
Quantitative dark adaptation as the magnitude of contraction of the pupil to light stimuli of various intensities (-2.9 to 0.1 log cd / m2) using a portable dark adaptometer. multilevel analysis of individual and specific stimulus done using mixed-effects models to obtain the relationship between SpO2 and responsive pupil. Among the 93 participants, the mean age was 54.9 ± 11.0 years, 48% were male, 44% are night blind, and the average SpO2 was 89.3% ± 3.4%.
The amount of contraction of the pupil is greater with lower SpO2 (p <0.01), and this relationship remained significant doses in some variables analysis (p = 0.047). The pupils are responsive to light stimulation under dark-adapted conditions exaggerated by hypoxemia and can serve as an early predictor of chronic mountain sickness. This unexpected associations potentially described as a sympathetic response excessive and unregulated hypoxemia at high altitude.
Dark Adaptation at High Altitude: An Unexpected Pupillary Response to Chronic Hypoxia in Andean Highlanders.
The difference between the Lesbian, Gay, Bisexual, Heterosexual Individuals, and those who reported other Identity in Open-Ended Response Level of Social Anxiety.
Previous research suggests that individuals with marginal level report higher sexual orientation of emotional distress (Cochran, 2001; Mayer, 2003), including a higher prevalence of social anxiety (Gilman et al, 2001 ;. Potoczniak, Aldea, & DeBlaere, 2007; Safren & Pantalone, 2006) compared to heterosexuals.
This research builds on previous research by examining the results on the identity of sexual minorities, including additional write-in response options. One hundred and eighty people participating in the online study in which they indicate their sexual orientation and completed measures of social anxiety.
The results showed that in a sample recruited in liberal urban population, lesbian / gay and heterosexual people rated the same level of social anxiety in four Liebowitz Social Anxiety Scale subscales (fear, avoidance, social, and performance; Liebowitz, 1987). Or, people who identified as bisexual, or indicate write-in sexual orientation rated significantly higher levels of social anxiety than heterosexual and lesbian groups / gay.
Description: A polyclonal antibody against AK3. Recognizes AK3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC
Description: A polyclonal antibody against AK3. Recognizes AK3 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200
Description: A polyclonal antibody against AK3. Recognizes AK3 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA
Description: A polyclonal antibody against AK3. Recognizes AK3 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA
Description: Human AK3 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.
Description: Description of target: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.UniRule annotation
<p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p>
<p><a href="/manual/evidences#ECO:0000255">More…</a></p> Manual assertion according to rulesiHAMAP-Rule:MF_031691 Publication
<p>Manually curated information for which there is published experimental evidence.</p>
<p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"Structure and expression of human mitochondrial adenylate kinase targeted to the mitochondrial matrix."_x005F_x005F_x000D_Noma T., Fujisawa K., Yamashiro Y., Shinohara M., Nakazawa A., Gondo T., Ishihara T., Yoshinobu K._x005F_x005F_x000D_Biochem. J. 358:225-232(2001) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY, SUBCELLULAR LOCATION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.146 ng/mL
The findings highlight the importance of offering write-in selection of sexual identity, as well as see the difference between the experience of sexual minority groups in all. Future studies should investigate the potential group differences in social anxiety throughout sexual orientation in a larger sample so that comparisons can be made between subgroups of group write-in responses, as well as investigating the potential contributors to the group differences.
