Healy, Katherine, Alain B. Labrique, J. Jaime Miranda, Robert H. Gilman, David Danz, Victor G. Davila-Roman, Luis Huicho, Fabiola León-Velarde, and William Checkley. dark adaptation at high altitude: Unexpected pupillary response to chronic hypoxia in the Andean highlands. High Alt Med Biol. 17: 208-213 mountain sickness, chronic-2016 is a maladaptive response to the high altitude (> 2500 m above sea level) and is characterized by excessive erythrocytosis and hypoxemia resulting from long-term hypobaric hypoxia.

No known early predictor of chronic mountain sickness and the diagnosis is based on the presence of excessive erythrocytosis and clinical features. Impaired dark adaptation, or the inability to visually adjust from high to low-light settings, occurs in response to mild hypoxia and can serve as an early predictor of hypoxemia and chronic mountain sickness. We aimed to evaluate the relationship between pupillary response assessed by adaptometry dark and daytime hypoxemia high Andean population aged ≥35 years living in Puno, Peru. Oxyhemoglobin saturation (SpO2) were recorded using a handheld pulse oximeter.

Quantitative dark adaptation as the magnitude of contraction of the pupil to light stimuli of various intensities (-2.9 to 0.1 log cd / m2) using a portable dark adaptometer. multilevel analysis of individual and specific stimulus done using mixed-effects models to obtain the relationship between SpO2 and responsive pupil. Among the 93 participants, the mean age was 54.9 ± 11.0 years, 48% were male, 44% are night blind, and the average SpO2 was 89.3% ± 3.4%.

The amount of contraction of the pupil is greater with lower SpO2 (p <0.01), and this relationship remained significant doses in some variables analysis (p = 0.047). The pupils are responsive to light stimulation under dark-adapted conditions exaggerated by hypoxemia and can serve as an early predictor of chronic mountain sickness. This unexpected associations potentially described as a sympathetic response excessive and unregulated hypoxemia at high altitude.

 Dark Adaptation at High Altitude: An Unexpected Pupillary Response to Chronic Hypoxia in Andean Highlanders.
Dark Adaptation at High Altitude: An Unexpected Pupillary Response to Chronic Hypoxia in Andean Highlanders.

The difference between the Lesbian, Gay, Bisexual, Heterosexual Individuals, and those who reported other Identity in Open-Ended Response Level of Social Anxiety.

Previous research suggests that individuals with marginal level report higher sexual orientation of emotional distress (Cochran, 2001; Mayer, 2003), including a higher prevalence of social anxiety (Gilman et al, 2001 ;. Potoczniak, Aldea, & DeBlaere, 2007; Safren & Pantalone, 2006) compared to heterosexuals.

This research builds on previous research by examining the results on the identity of sexual minorities, including additional write-in response options. One hundred and eighty people participating in the online study in which they indicate their sexual orientation and completed measures of social anxiety.

The results showed that in a sample recruited in liberal urban population, lesbian / gay and heterosexual people rated the same level of social anxiety in four Liebowitz Social Anxiety Scale subscales (fear, avoidance, social, and performance; Liebowitz, 1987). Or, people who identified as bisexual, or indicate write-in sexual orientation rated significantly higher levels of social anxiety than heterosexual and lesbian groups / gay.

GTP:AMP Phosphotransferase AK3, Mitochondrial (AK3) Antibody

abx334022-20g 20 µg
EUR 162.5

GTP:AMP Phosphotransferase AK3, Mitochondrial (AK3) Antibody

abx334022-50g 50 µg
EUR 250

GTP:AMP Phosphotransferase AK3, Mitochondrial (AK3) Antibody

abx003544-100l 100 µl
EUR 400

GTP:AMP Phosphotransferase AK3, Mitochondrial (AK3) Antibody

abx003544-20l 20 µl
EUR 175

GTP:AMP Phosphotransferase AK3, Mitochondrial (AK3) Antibody

abx003544-50l 50 µl
EUR 275

AK3 siRNA

20-abx900245
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  • 15 nmol
  • 30 nmol

AK3 siRNA

20-abx907118
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  • 15 nmol
  • 30 nmol

AK3 siRNA

20-abx907119
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  • 15 nmol
  • 30 nmol

AK3 antibody

10R-1020 100 ul
EUR 321
Description: Mouse monoclonal AK3 antibody

AK3 antibody

10R-3231 100 ul
EUR 709
Description: Mouse monoclonal AK3 antibody

AK3 antibody

10R-3232 100 ul
EUR 709
Description: Mouse monoclonal AK3 antibody

AK3 antibody

10R-3233 100 ul
EUR 709
Description: Mouse monoclonal AK3 antibody

AK3 antibody

10R-3235 100 ul
EUR 709
Description: Mouse monoclonal AK3 antibody

AK3 antibody

10R-3236 100 ul
EUR 709
Description: Mouse monoclonal AK3 antibody

AK3 antibody

10R-3237 100 ul
EUR 709
Description: Mouse monoclonal AK3 antibody

AK3 Antibody

1-CSB-PA883438LA01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against AK3. Recognizes AK3 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

AK3 Antibody

E94694 100μg
EUR 255
Description: Available in various conjugation types.

AK3 Antibody

E312740 200ul
EUR 275
Description: Available in various conjugation types.

AK3 antibody

70R-15645 50 ul
EUR 289
Description: Rabbit polyclonal AK3 antibody

AK3 antibody

70R-5874 50 ug
EUR 467
Description: Rabbit polyclonal AK3 antibody raised against the N terminal of AK3

AK3 Antibody

1-CSB-PA001511GA01HU
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  • 150ul
  • 50ul
Description: A polyclonal antibody against AK3. Recognizes AK3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC

AK3 Antibody

GWB-MU567I 50ug Ask for price

Ak3 Antibody

GWB-MU568A 50ug Ask for price

AK3 Antibody

MBS7103678-005mg 0.05mg
EUR 190

AK3 Antibody

MBS7103678-01mg 0.1mg
EUR 270

AK3 Antibody

MBS7103678-5x01mg 5x0.1mg
EUR 1205

AK3 Antibody

MBS8576429-01mLAF405L 0.1mL(AF405L)
EUR 565

AK3 Antibody

MBS8576429-01mLAF405S 0.1mL(AF405S)
EUR 565

AK3 Antibody

MBS8576429-01mLAF610 0.1mL(AF610)
EUR 565

AK3 Antibody

MBS8576429-01mLAF635 0.1mL(AF635)
EUR 565

AK3 Antibody

MBS8576429-02mL 0.2mL
EUR 345

AK3 antibody

MBS831549-01mL 0.1mL
EUR 1095

AK3 antibody

MBS831549-5x01mL 5x0.1mL
EUR 4770

AK3 antibody

MBS831688-01mL 0.1mL
EUR 1095

AK3 antibody

MBS831688-5x01mL 5x0.1mL
EUR 4770

AK3 antibody

MBS830103-01mL 0.1mL
EUR 1095

AK3 antibody

MBS830103-5x01mL 5x0.1mL
EUR 4770

AK3 Antibody

MBS8500819-01mg 0.1mg
EUR 325

AK3 Antibody

MBS8500819-01mLAF405L 0.1mL(AF405L)
EUR 565

AK3 Antibody

MBS8500819-01mLAF405S 0.1mL(AF405S)
EUR 565

AK3 Antibody

MBS8500819-01mLAF610 0.1mL(AF610)
EUR 565

AK3 Antibody

MBS8500819-01mLAF635 0.1mL(AF635)
EUR 565

AK3 antibody

MBS830201-01mL 0.1mL
EUR 1095

AK3 antibody

MBS830201-5x01mL 5x0.1mL
EUR 4770

AK3 antibody

MBS830776-01mL 0.1mL
EUR 1095

AK3 antibody

MBS830776-5x01mL 5x0.1mL
EUR 4770

AK3 antibody

MBS200020-005mL 0.05mL
EUR 260

AK3 antibody

MBS200020-01mL 0.1mL
EUR 345

AK3 antibody

MBS200020-5x01mL 5x0.1mL
EUR 1300

AK3 antibody

MBS533741-01mL 0.1mL
EUR 1095

AK3 antibody

MBS533741-5x01mL 5x0.1mL
EUR 4770

GTP:AMP Phosphotransferase AK3, Mitochondrial (AK3) Antibody (HRP)

20-abx335898
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

GTP:AMP Phosphotransferase AK3, Mitochondrial (AK3) Antibody (HRP)

abx335898-100g 100 µg
EUR 362.5

GTP:AMP Phosphotransferase AK3, Mitochondrial (AK3) Antibody (HRP)

abx335898-20g 20 µg
EUR 162.5

GTP:AMP Phosphotransferase AK3, Mitochondrial (AK3) Antibody (HRP)

abx335898-50g 50 µg
EUR 250

GTP:AMP Phosphotransferase AK3, Mitochondrial (AK3) Antibody (FITC)

20-abx335899
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

GTP:AMP Phosphotransferase AK3, Mitochondrial (AK3) Antibody (FITC)

abx335899-100g 100 µg
EUR 362.5

GTP:AMP Phosphotransferase AK3, Mitochondrial (AK3) Antibody (FITC)

abx335899-20g 20 µg
EUR 162.5

GTP:AMP Phosphotransferase AK3, Mitochondrial (AK3) Antibody (FITC)

abx335899-50g 50 µg
EUR 250

GTP:AMP Phosphotransferase AK3, Mitochondrial (AK3) Antibody (Biotin)

20-abx335900
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

GTP:AMP Phosphotransferase AK3, Mitochondrial (AK3) Antibody (Biotin)

abx335900-100g 100 µg
EUR 362.5

GTP:AMP Phosphotransferase AK3, Mitochondrial (AK3) Antibody (Biotin)

abx335900-20g 20 µg
EUR 162.5

GTP:AMP Phosphotransferase AK3, Mitochondrial (AK3) Antibody (Biotin)

abx335900-50g 50 µg
EUR 250

Rat GTP:AMP Phosphotransferase AK3, Mitochondrial (AK3) ELISA Kit

abx529309-96tests 96 tests
EUR 687.5

AK3 siRNA (Rat)

MBS8230391-15nmol 15nmol
EUR 405

AK3 siRNA (Rat)

MBS8230391-30nmol 30nmol
EUR 565

AK3 siRNA (Rat)

MBS8230391-5x30nmol 5x30nmol
EUR 2450

AK3 Rabbit pAb

E2514694 100ul
EUR 225
Description: Available in various conjugation types.

AK3 Rabbit pAb

A4694-100ul 100 ul
EUR 369.6

AK3 Rabbit pAb

A4694-200ul 200 ul
EUR 550.8

AK3 Rabbit pAb

A4694-20ul 20 ul
EUR 219.6

AK3 Rabbit pAb

A4694-50ul 50 ul
EUR 267.6

AK3 cDNA Clone

MBS1277807-001mgPlasmid02mLGlycerolStock 0.01mgPlasmid+0.2mLGlycerol-Stock
EUR 200

AK3 cDNA Clone

MBS1277807-5x001mgPlasmid5x02mLGlycerolStock 5x0.01mgPlasmid+5x0.2mLGlycerol-Stock
EUR 855

AK3 Rabbit pAb

MBS8549558-01mL 0.1mL
EUR 305

AK3 Rabbit pAb

MBS8549558-01mLAF405L 0.1mL(AF405L)
EUR 565

AK3 Rabbit pAb

MBS8549558-01mLAF405S 0.1mL(AF405S)
EUR 565

AK3 Rabbit pAb

MBS8549558-01mLAF610 0.1mL(AF610)
EUR 565

AK3 Rabbit pAb

MBS8549558-01mLAF635 0.1mL(AF635)
EUR 565

AK3 Rabbit pAb

A4694 100μL
EUR 623.48

AK3 siRNA (Mouse)

MBS8231750-15nmol 15nmol
EUR 405

AK3 siRNA (Mouse)

MBS8231750-30nmol 30nmol
EUR 565

AK3 siRNA (Mouse)

MBS8231750-5x30nmol 5x30nmol
EUR 2450

AK3 siRNA (Human)

MBS8225470-15nmol 15nmol
EUR 405

AK3 siRNA (Human)

MBS8225470-30nmol 30nmol
EUR 565

AK3 siRNA (Human)

MBS8225470-5x30nmol 5x30nmol
EUR 2450

anti- AK3 antibody

FNab00246 100µg
EUR 606.3
Description: Antibody raised against AK3

AK3 cloning plasmid

CSB-CL883438HU-10ug 10ug
EUR 279.6
Description: A cloning plasmid for the AK3 gene.

AK3 Blocking Peptide

33R-6011 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of AK3 antibody, catalog no. 70R-5874

AK3 Polyclonal Antibody

30599 100ul
EUR 439

AK3 Polyclonal Antibody

30599-100ul 100ul
EUR 302.4

AK3 Polyclonal Antibody

30599-50ul 50ul
EUR 224.4

AK3 Polyclonal Antibody

MBS9126356-002mL 0.02mL
EUR 200

AK3 Polyclonal Antibody

MBS9126356-005mL 0.05mL
EUR 255

AK3 Polyclonal Antibody

MBS9126356-01mL 0.1mL
EUR 345

AK3 Polyclonal Antibody

MBS9126356-02mL 0.2mL
EUR 545

AK3 Polyclonal Antibody

MBS9126356-5x02mL 5x0.2mL
EUR 2265

AK3 Polyclonal Antibody

MBS2555867-006mL 0.06mL
EUR 180

AK3 Polyclonal Antibody

MBS2555867-012mL 0.12mL
EUR 260

AK3 Polyclonal Antibody

MBS2555867-02mL 0.2mL
EUR 405

AK3 Polyclonal Antibody

MBS2555867-5x02mL 5x0.2mL
EUR 1725

AK3 Polyclonal Antibody

MBS9433730-005mL 0.05mL
EUR 300

AK3 Polyclonal Antibody

MBS9433730-01mL 0.1mL
EUR 390

AK3 Polyclonal Antibody

MBS9433730-5x01mL 5x0.1mL
EUR 1610

Rat Ak3 ELISA Kit

ELI-38174r 96tests
EUR 756

Human AK3 ELISA KIT

EF007678 96tests
EUR 566

Rat AK3 shRNA Plasmid

20-abx985290
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  • 150 µg
  • 300 µg

AK3 (untagged) - Homo sapiens adenylate kinase 3 (AK3), transcript variant 2

SC329576 10 µg Ask for price

AK3 (untagged) - Homo sapiens adenylate kinase 3 (AK3), transcript variant 3

SC329577 10 µg Ask for price

AK3 (untagged) - Homo sapiens adenylate kinase 3 (AK3), transcript variant 5

SC329578 10 µg Ask for price

AK3 (untagged) - Homo sapiens adenylate kinase 3 (AK3), transcript variant 6

SC329579 10 µg Ask for price

Mouse AK3 shRNA Plasmid

20-abx974665
  • Ask for price
  • Ask for price
  • 150 µg
  • 300 µg

Human AK3 shRNA Plasmid

20-abx959407
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  • Ask for price
  • 150 µg
  • 300 µg

Human AK3 Protein Lysate

MBS137053-002mg 0.02mg
EUR 365

Human AK3 Protein Lysate

MBS137053-5x002mg 5x0.02mg
EUR 1410

AK3 Antibody, HRP conjugated

1-CSB-PA883438LB01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against AK3. Recognizes AK3 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

AK3 Recombinant Protein (Rat)

RP189674 100 ug Ask for price

AK3 Antibody, HRP conjugated

MBS7103679-005mg 0.05mg
EUR 190

AK3 Antibody, HRP conjugated

MBS7103679-01mg 0.1mg
EUR 270

AK3 Antibody, HRP conjugated

MBS7103679-5x01mg 5x0.1mg
EUR 1205

AK3 Antibody, FITC conjugated

1-CSB-PA883438LC01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against AK3. Recognizes AK3 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

AK3 Antibody, FITC conjugated

MBS7103680-005mg 0.05mg
EUR 190

AK3 Antibody, FITC conjugated

MBS7103680-01mg 0.1mg
EUR 270

AK3 Antibody, FITC conjugated

MBS7103680-5x01mg 5x0.1mg
EUR 1205

AK3 Recombinant Protein (Human)

RP000859 100 ug Ask for price

AK3 Recombinant Protein (Mouse)

RP115100 100 ug Ask for price

Recombinant Human AK3 protein

MBS1562060-005mg 0.05mg
EUR 320

Recombinant Human AK3 protein

MBS1562060-01mg 0.1mg
EUR 410

Recombinant Human AK3 protein

MBS1562060-5x01mg 5x0.1mg
EUR 1520

AK3 Antibody, Biotin conjugated

1-CSB-PA883438LD01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against AK3. Recognizes AK3 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

AK3 Antibody, Biotin conjugated

MBS7103681-005mg 0.05mg
EUR 190

AK3 Antibody, Biotin conjugated

MBS7103681-01mg 0.1mg
EUR 270

AK3 Antibody, Biotin conjugated

MBS7103681-5x01mg 5x0.1mg
EUR 1205

AK3 Polyclonal Conjugated Antibody

C30599 100ul
EUR 476.4

AK3 Polyclonal Conjugated Antibody

MBS9441775-01mLAF350 0.1mL(AF350)
EUR 480

AK3 Polyclonal Conjugated Antibody

MBS9441775-01mLAF405 0.1mL(AF405)
EUR 480

AK3 Polyclonal Conjugated Antibody

MBS9441775-01mLAF488 0.1mL(AF488)
EUR 480

AK3 Polyclonal Conjugated Antibody

MBS9441775-01mLAF555 0.1mL(AF555)
EUR 480

AK3 Polyclonal Conjugated Antibody

MBS9441775-01mLBiotin 0.1mL(Biotin)
EUR 480

AK3 (GFP-tagged) - Homo sapiens adenylate kinase 3 (AK3), transcript variant 3

RG231890 10 µg Ask for price

AK3 (GFP-tagged) - Homo sapiens adenylate kinase 3 (AK3), transcript variant 5

RG231891 10 µg Ask for price

AK3 (GFP-tagged) - Homo sapiens adenylate kinase 3 (AK3), transcript variant 6

RG231892 10 µg Ask for price

AK3 (GFP-tagged) - Homo sapiens adenylate kinase 3 (AK3), transcript variant 2

RG232029 10 µg Ask for price

AK3 (NM_016282) Human Over-expression Lysate

LS050808 100ug
EUR 628
Description: Transient overexpression lysate of adenylate kinase 3 (AK3), nuclear gene encoding mitochondrial protein

Ak3 ORF Vector (Rat) (pORF)

ORF063226 1.0 ug DNA
EUR 607.2

Ak3 ORF Vector (Mouse) (pORF)

ORF038368 1.0 ug DNA
EUR 607.2

AK3 ORF Vector (Human) (pORF)

ORF000287 1.0 ug DNA
EUR 114

AK3 Antibody (C-term H38)

MBS9206499-008mL 0.08mL
EUR 210

AK3 Antibody (C-term H38)

MBS9206499-04mL 0.4mL
EUR 430

AK3 Antibody (C-term H38)

MBS9206499-5x04mL 5x0.4mL
EUR 1910

AK3 (Myc-DDK tagged) - Homo sapiens adenylate kinase 3 (AK3), transcript variant 3

RC231890 10 µg Ask for price

AK3 (Myc-DDK tagged) - Homo sapiens adenylate kinase 3 (AK3), transcript variant 5

RC231891 10 µg Ask for price

AK3 (Myc-DDK tagged) - Homo sapiens adenylate kinase 3 (AK3), transcript variant 6

RC231892 10 µg Ask for price

AK3 (Myc-DDK tagged) - Homo sapiens adenylate kinase 3 (AK3), transcript variant 2

RC232029 10 µg Ask for price

AK3 Antibody (N-term F210)

MBS9208026-008mL 0.08mL
EUR 210

AK3 Antibody (N-term F210)

MBS9208026-04mL 0.4mL
EUR 430

AK3 Antibody (N-term F210)

MBS9208026-5x04mL 5x0.4mL
EUR 1910

Human AK3 knockout cell line

ABC-KH0449 1 vial Ask for price
Description: Human AK3 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Human AK3 knockdown cell line

ABC-KD0449 1 vial Ask for price
Description: Human AK3 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human AK3 Protein Lysate 20ug

IHUAK3PLLY20UG each
EUR 213
Description: Human AK3 Protein Lysate 20ug

AK3 ELISA Kit (Human) (OKCD00960)

OKCD00960 96 Wells
EUR 997.2
Description: Description of target: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.UniRule annotation <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More…</a></p> Manual assertion according to rulesiHAMAP-Rule:MF_031691 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"Structure and expression of human mitochondrial adenylate kinase targeted to the mitochondrial matrix."_x005F_x005F_x000D_Noma T., Fujisawa K., Yamashiro Y., Shinohara M., Nakazawa A., Gondo T., Ishihara T., Yoshinobu K._x005F_x005F_x000D_Biochem. J. 358:225-232(2001) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY, SUBCELLULAR LOCATION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.146 ng/mL

AK3 Peptide - N-terminal region

MBS3237995-01mg 0.1mg
EUR 180

AK3 Peptide - N-terminal region

MBS3237995-5x01mg 5x0.1mg
EUR 730

Ak3 Peptide - C-terminal region

MBS3237996-01mg 0.1mg
EUR 180

Ak3 Peptide - C-terminal region

MBS3237996-5x01mg 5x0.1mg
EUR 730

Adenylate Kinase 3 (AK3) Antibody

20-abx110852
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  • 150 ul
  • 50 ul

Adenylate Kinase 3 (AK3) Antibody

20-abx128304
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  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Adenylate Kinase 3 (AK3) Antibody

abx033891-400ul 400 ul
EUR 627.6

Adenylate Kinase 3 (AK3) Antibody

abx033891-80l 80 µl
EUR 343.2

Adenylate Kinase 3 (AK3) Antibody

abx230246-100ug 100 ug
EUR 577.2

Adenylate Kinase 3 (AK3) Antibody

20-abx171091
  • Ask for price
  • Ask for price
  • 1 mg
  • 200 ug

The findings highlight the importance of offering write-in selection of sexual identity, as well as see the difference between the experience of sexual minority groups in all. Future studies should investigate the potential group differences in social anxiety throughout sexual orientation in a larger sample so that comparisons can be made between subgroups of group write-in responses, as well as investigating the potential contributors to the group differences.